Ciclopirox olamine: which products contain it?

The ciclopirox olamine is a hydroxypyridinone derivative with antifungal, antibacterial, and anti-inflammatory properties. It acts by disrupting iron metabolism within fungal cells, which inhibits the synthesis of enzymes essential for their survival. Unlike many antifungal agents that target cell membranes, ciclopirox employs a broader mechanism of action, making the emergence of resistance difficult. Furthermore, ciclopirox olamine is a broad-spectrum antifungal. Thanks to this favorable pharmacological profile, the ciclopirox olamine is included in various products designed to combat skin or nail mycoses, dandruff, and seborrheic dermatitis.

• Ciclopirox olamine shampoos.

  Ciclopirox olamine is primarily incorporated into antifungal shampoos, often at concentrations of 1%. These formulations target scalps affected by seborrheic dermatitis or exhibiting dandruff. As a reminder, dandruff and seborrheic dermatitis result from a scalp imbalance associated with accelerated cell renewal, leading to an accumulation of scales on the surface and promoting the proliferation of yeasts of the genusMalassezia. Ciclopirox olamine can act on these different parameters, hence its presence in anti-dandruff shampoos.

  Shampoos containing ciclopirox olamine are generally used two to three times a week initially, and then, once dandruff has subsided, a weekly application is sufficient to prevent relapses.

• Ciclopirox olamine lotions or serums for the scalp.

  Ciclopirox olamine can also be found in hair serums or lotions. These leave-on products maintain prolonged contact with the scalp, thereby extending antifungal action. Ciclopirox olamine serums or lotions may also be beneficial for individuals with sensitive or very dry scalps who cannot tolerate frequent washing but still suffer from dandruff.

• Ciclopirox olamine creams.

  In dermatology, ciclopirox olamine is also included in creams formulated to treat fungal infections, whether they occur on the face or in the genital area (vulvar mycoses). These formulations are often made at a 1% concentration and are applied to clean, dry skin.

  The duration of treatment with ciclopirox olamine creams varies with the severity of the infection, but generally they are applied twice daily for three weeks.

• Ciclopirox olamine nail polish.

  In the context of onychomycoses, also known as nail fungal infections, the ciclopirox olamine is available as a medicated nail lacquer, typically at 8%. This formulation allows localized application and progressive penetration of the active ingredient through the nail plate to the nail bed. Thanks to its antifungal properties and strong adhesion to keratin, ciclopirox olamine can manage the infection without the need to file the nail. Ciclopirox olamine nail lacquers are particularly useful in cases of moderate onychomycosis or as an adjunct to oral antifungal therapy.

  Ciclopirox olamine nail lacquers are applied once daily to each infected nail for three to six months.