Acne: What can CBD contribute?

Given the significant role of the endocannabinoid system in the skin, current research has focused on the role of phytocannabinoids as potential therapeutic options for various skin disorders, such as acne. Recently, cannabidiol (CBD) has been suggested as a new treatment option for acne. In addition to its known anti-inflammatory activity, it would simultaneously target the various pathological pathways underlying acne physiology, all with a notable side effect profile.

• CBD, a Sebostatic Agent: CBD has the ability to "normalize" the pathologically high sebum production from sebaceous glands seen in acne-prone skin. A study revealed that CBD administered to cultured human sebocytes and human skin organ cultures reduced the cellular proliferation of sebocytes through the activation of TRPV4 (Transient Receptor Potential Vanilloid-4) ion channels, without compromising viability, and thus significantly reducing sebum production due to the holocrine mechanism. It is also capable of inhibiting the lipogenic actions of various compounds, including arachidonic acid, linoleic acid, and testosterone.

• The Complex Anti-Inflammatory Effect of CBD: CBD also exerts anti-inflammatory actions in keratinocytes, which are mediated by the increase of TRIB3 and the inactivation of NF-κB and MAPK signaling pathways. This is illustrated by a decrease in the expression levels of inflammatory mediators in skin cells, including TNF-α, IL-6, IL-8, and IL-1β. In the case of acne, it thus helps to modulate the inflammation of the sebaceous glands induced by C. acnes. Therefore, it helps to soothe and fade acne inflammation without presenting unpleasant effects. This anti-inflammatory action of CBD extends to the prevention of symptoms related to acne outbreaks such as redness.

• CBD and its Bactericidal Mechanism: CBD also exhibits antibacterial and antifungal actions. This phytocannabinoid can reduce the growth of several bacteria, including the Staphylococcus aureus highly resistant, the Streptococcus pneumoniae and the Clostridioides difficile, by altering the membrane.

• CBD in the face of hyperkeratinization: Finally, it has also been demonstrated that CBD inhibits the proliferation of hyperproliferative keratinocytes. These findings thus show that CBD can help prevent the buildup of epidermal cells that lead to sebum retention and pore obstruction.

In close correlation with the results in vitro and ex vivo, several placebo-controlled clinical evaluations have been conducted and have shown that the topical application of a CBD-based formula statistically reduces the number of acne lesions (primarily inflammatory lesions), sebum production, and the onset of erythema. Collectively, the obtained results suggest that, thanks to its properties of regulating sebum overproduction, its anti-sebocyte, antibacterial, anti-proliferative, and anti-inflammatory effects combined, CBD has the potential to be a promising universal therapeutic agent in the fight against acne by thus influencing all aspects of this skin pathology.

CBD can be applied directly and locally to the affected skin areas. To promote its percutaneous penetration and distribution, CBD oils, balms, and creams are among the most effective means to benefit from its effects against acne, due to its lipophilic nature.

In order to optimize effectiveness, CBD is often combined with other active ingredients used in acne treatments, such as vitamins or other anti-inflammatory compounds (Centella asiatica, salicylic acid, etc.). Various clinical studies show that concentrations of 2.5 to 10 μg/mL of CBD are sufficient to observe a reduction in acne lesions and improve tolerance with reduced local side effects, and this for an application of twice a day for an average of one and a half months.

It is important to clarify that CBD currently serves as a therapeutic supplement against acne and it is recommended to discuss the subject in advance with your doctor, especially if you are concurrently taking any medication.