Are stress and eczema connected?

When we examine the biological mechanisms at play, we find that stress increases skin inflammation by triggering the degranulation of mast cells, immune cells involved in allergic reactions. This is mediated by neuropeptides released by cutaneous nerve fibers: CRH (Corticotropin Releasing Hormone), neurotensin, substance P, and other tachykinins. The release of these hormones triggers a cascade of reactions leading to the release of mediators responsible for the itchiness of eczema and the dilation of blood vessels.

Furthermore, cortisol, the stress hormone, affects the skin barrier by weakening it. It first reduces the synthesis of lipids, molecules that make up the stratum corneum and help maintain skin hydration. A reduction in the production of these lipids can lead to dry and easily irritable skin. Cortisol also increases the skin inflammation by stimulating the synthesis of pro-inflammatory cytokines, molecules involved in several inflammatory phenomena and implicated in eczema.

Stress is a common and multifactorial element in our lives: professional interviews, medical visits, bereavement... Unfortunately, it is not possible to alter any potential genetic susceptibility to stress or to change one's life when suffering from eczema. However, several methods can help to better respond to stress.

Ahealthy lifestyle notably allows for a better response to stress: regular practice of a sport, pleasant surroundings, avoidance of addictive products, regular sleep... Although there are few studies due to significant methodological difficulties and the unique nature of each patient, psychotherapies seem to have a role in the treatment of inflammatory skin diseases.

Furthermore, in general, psychosocial interventions have demonstrated effects on immunity. To better manage stress, cognitive-behavioral therapies such as relaxation or Schultz's autogenic training can be beneficial. Yoga and meditation can also help, as can techniques for self-assertion, cognitive restructuring, or non-violent conflict resolution. The goal is to develop a better ability to cope with stressful situations. However, it should be noted that the benefit of all these techniques for atopic dermatitis itself has not been proven.

Finally, while stress can trigger eczema flare-ups, it is likely that this disease itself is a cause of stress, creating a vicious cycle. By focusing on alleviating the symptoms of dermatitis, we likely also reduce stress, thereby improving the prognosis of the disease. This theory remains to be proven, but it seems worthwhile to keep it in mind.