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Profile: Erythrodermic Psoriasis

Definition: Erythrodermic psoriasis is an exceptionally rare but very severe form of psoriasis, characterized by erythematous-squamous lesions (skin redness and scales) covering more than 90% of the body. It is also accompanied by fever, pain, potential heart failure, possible edema, and chills. In this case, the skin no longer performs its protective barrier function, which can lead to a risk of superinfection and dehydration. Erythrodermic psoriasis accounts for 1 to 2.25% of cases.
Internal and external causes: Some medications (lithium, anti-malarials); infections; sudden cessation of an intensive treatment with oral or topical corticosteroids.
How to reduce or eliminate: Emergency hospitalization involving the administration of intravenous fluids and regulation of body temperature; use of emollients and wet dressings; intake of immunosuppressants (methotrexate or cyclosporine); treatment with biotherapies using anti-TNF-α (efalizumab, infliximab, etanercept or alefacept); use of IL-12/23 inhibitors (ustekinumab).
Preventative steps to take: /

Related articles: Psoriasis érythrodermique.