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How is salicylic acid produced?

How is salicylic acid produced?

Salicylic acid is a beta-hydroxy acid known for over 6,000 years for its therapeutic properties. It is found in willow bark, from which it gets its name, as well as in many fruits (grapes, plums, apricots...) and vegetables (broccoli, cucumber, spinach, sweet potato...). Its soothing, keratolytic, and sebum-regulating properties make it a valuable ally in the treatment of acne and blemishes. Here's a focus on its history and extraction process.

Process of obtaining salicylic acid.

The willow is a shrub belonging to the Salicaceae family. The use of its bark spans millennia: it was from its extracts that in 1828, Johannes BUCHNER prepared salicin, an active ingredient with powerful anti-inflammatory properties. The hydrolysis of this molecule releases D-glucose and salicylic alcohol, a compound that can then be oxidized to give birth to thesalicylic acid.

In 1860, salicylic acid was first synthesized by the Kolbe-Schmidt reaction. Even today, this synthetic pathway is used to produce this active ingredient found in several Typology skincare products. The process of obtaining it is as follows: sodium phenate reacts with carbon dioxide under pressure, thus producing sodium salicylate. This then precipitates with sulfuric acid to yield the final product, salicylic acid.

Main applications of salicylic acid.

In medicine, salicylic acid is traditionally used for its effect as an exfoliant in squamous pathologies: it effectively treats warts and psoriasis. The destruction of desmosomes that connect keratinocytes and the inhibition of prostaglandin production constitute its two biological modes of action.

In dermocosmetics, salicylic acid is particularly recommended for the care of oily skin due to its comedolytic and antimicrobial properties. It also helps to stimulate cell renewal and to brighten dull and gray complexions. It is also found in anti-dandruff shampoos (for oily flakes) and in hair care products, to restore shine and luster to the hair.

In which Typology skincare products can you find salicylic acid?

Typology has developed two skincare treatments with salicylic acid:

  • The Purifying Tonic :

    Unlike the serum, the toner can be applied all over the face as it has a lower concentration of salicylic acid. Apply it with a cotton pad to the face and neck after they have been cleaned, avoiding the eye area, preferably in the evening, before the daily serum or night cream.

  • The localized imperfection serum :

    Containing 2% salicylic acid and 1% zinc, this serum purifies the skin and provides a comprehensive anti-bacterial action. It is applied in the evening, locally and in small amounts. One drop per blemish is sufficient; initial results can be observed after three days.

Sources

  • WHITE J.W. Salicylic Acid: Its History and Uses, Glasgow Medical Journal (1882).

  • JESKEY H. & al. The Kolbe-Schmitt Reaction. Chemical Review (1957).

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