What are the benefits of Ophiopogon japonicus extract on the skin?

Studies have shown that the extract of Ophiopogon japonicus root can soothe and calm irritated skin due to its anti-inflammatory properties, potentially benefiting individuals with sensitive or reactive skin. Phytochemical studies have revealed that the anti-inflammatory activity of Ophiopogon japonicus roots may come from certain polysaccharides, particularly β-fructans. In addition to polysaccharides, other findings have shown that homoisoflavonoids are also compounds with anti-inflammatory activity.

These various compounds have demonstrated their ability to significantly reduce the production of nitric oxide and pro-inflammatory mediators IL-1β and IL-6, by inhibiting the MAPK signaling pathway. It's important to understand that excessive production of nitric oxide, IL-1β, and IL-6 in immune cells (macrophages) leads to an acute and chronic inflammatory response. These findings highlight the great potential of theOphiopogon japonicus as a new botanical ingredient to alleviate inflammatory diseases.

A clinical study was undertaken and demonstrated the potential effectiveness of oligofructosanes derived fromOphiopogon japonicus in alleviating atopic symptoms and extending the remission phase between two flare-ups in children and adults suffering from atopic dermatitis of mild to moderate severity.

High levels of free radicals can lead to all sorts of damage that disrupts skin function, as they can non-specifically oxidize all classes of biological macromolecules, including lipids, proteins, and nucleic acids. However, studies have revealed that Japanese lilyturf is a potential source of antioxidant-active compounds, which can help eliminate free radicals and protect skin cells from oxidative stress. It has been revealed that the antioxidant capabilities of the extract from Ophiopogon japonicus depend on its total content of homoisoflavonoid compounds. Indeed, MA C. and his team have shown that homoisoflavonoids, particularly methylophiopogonanone A and methylophiopogonanone B, derived from the roots of Ophiopogon japonicus have shown strong antioxidant activity following several in vitro tests.

On the other hand, it has also been reported that purified polysaccharides derived from the tubers ofOphiopogon japonicus also have a strong ability to donate hydrogen atoms and trap free radicals, after in vitroevaluation. According to studies, this antioxidant activity of polysaccharides mainly depends on their structural characteristics, and seems to be partially due to their hexuronic acid content and sulfate group for their chelating property. All these results suggest that the tubers ofOphiopogon japonicus can be used as antioxidants and that this free radical protection can potentially help to prevent premature skin aging.

However, more in-depth studies to determine the exact mechanism underlying the antioxidant activity of the extract ofOphiopogon japonicusare necessary, as well as clinical studies to validate this hypothesis.