What should you know about benzoyl peroxide?

The technique that allows the synthesis of benzoyl peroxide unfolds in 3 major steps. This process includes a Grignard reaction which causes bromobenzene to react with magnesium in the presence of an anhydrous solvent, often ether, to form phenylmagnesium bromide, also known as Grignard reagent. This then reacts with carbon dioxide (CO₂), leading to the formation of a carboxylate salt. The addition of hydrochloric acid (HCl) releases benzoic acid (2) in the form of a crystallized solid.

Benzoic acid reacts with thionyl chloride (SOCl₂) to form benzoyl chloride (3). This step involves the substitution of the hydroxyl (-OH) group in the acid with a chlorine atom, generating a more reactive acid derivative, benzoyl chloride (3). This then reacts with hydrogen peroxide (H₂O₂) in the presence of a base (NaOH). This reaction results in the formation of benzoyl peroxide (1) through the interaction of the two acyl (C=O) groups with the peroxide oxygen (-O-O-).

The benzoyl peroxide has several properties that make it a versatile active ingredient in the management of acne. It is recognized for its antibacterial, sebostatic, keratolytic, and anti-inflammatory effects, thus effectively reducing blemishes. Moreover, these properties could also be beneficial in the management of folliculitis and seborrheic dermatitis. Finally, in combination with retinoids such as adapalene, benzoyl peroxide would help to decrease the appearance of acne scars, by promoting cell renewal and preventing inflammation.

• Benzoyl Peroxide: An antibacterial agent.

  When applied to the skin, benzoyl peroxide breaks down into benzoic acid while releasing reactive oxygen species (ROS). These highly reactive molecules attack the DNA and proteins of Cutibacterium acnes, the bacteria responsible for acne, thereby eliminating them.

• Benzoyl Peroxide is an anti-inflammatory.

  Benzoyl peroxide is primarily known for its antibacterial properties, but it also exhibits indirect anti-inflammatory effects. By eliminating bacteria Cutibacterium acnes, which are responsible for acne, it reduces the inflammatory response these bacteria trigger in the skin. Its ability to decrease the factors that trigger inflammation gives it an indirect beneficial effect on redness and irritation.

• Benzoyl peroxide has a sebostatic property.

  Benzoyl peroxide also has a direct sebostatic action and works to reduce the stimulation of the sebaceous glands. This property is particularly beneficial for individuals with oily skin as it helps to keep the amount of sebum synthesized under control.

• Benzoyl peroxide has a keratolytic action.

  Hyperkeratinization is one of the symptoms of acne. It manifests as an excessive production of keratin that accumulates in the follicles and leads to a thickening of the horny layer. Benzoyl peroxide plays an exfoliating role due to specific molecules dissociated from benzoyl peroxide during its application, such as the benzoyl radical and reactive oxygen species. These unstable molecules then split to form carbon dioxide which promotes cellular renewal by stimulating the detachment of dead cells from the skin surface.

The use of benzoyl peroxide in skincare requires certain precautions due to its potential side effects.

Benzoyl peroxide can cause skin reactions similar to burns upon application. This risk can be heightened by a high concentration of benzoyl peroxide and by applying the product in excessive amounts. Moreover, the application of benzoyl peroxide can lead to risks of discoloration of hair and clothing in case of direct contact with the product. Therefore, it is advised to apply it in the evening with hair tied back and to wait half an hour before going to bed, to avoid discoloring bed sheets. Furthermore, benzoyl peroxide is not recommended for pregnant women and children under 12 years of age.

Furthermore, benzoyl peroxide is potentially phototoxic and can increase the skin's sensitivity to sunlight. Indeed, when exposed to UV rays, reactive oxygen species (ROS) are produced. The oxidative stress caused by ROS damages DNA, lipids, and proteins, thus affecting the health of skin tissues. This reaction results in adverse effects such as red patches, burns similar to sunburn, erythema, or hyperpigmentation. This is why benzoyl peroxide is preferably applied in the evening. Sun protection is then necessary the following day.