Sebum is often blamed when it comes to dandruff. This lipid film, secreted by the sebaceous glands, actually serves an essential protective function : it lubricates the scalp, maintains hydration, and forms a natural barrier against external aggressors. But, as is often the case in biology, balance is key: too little sebum weakens the skin, while too much alters the cutaneous ecosystem.
The previously cited ZHANG study also analyzed the relationship between sebum and dandruff. The researchers found that sebum production varies with age: it peaks between 20 and 39 years old, then tends to decline after 40. At first glance, one might expect younger individuals to be more affected by dandruff. However, the opposite is true: older adults often exhibit more flakes despite having less abundant sebum. This paradox shows that sebum alone is not the direct culprit, but that it acts in interaction with the microbiome and the skin barrier.
The effect that sebum depends primarily on its composition. Rich in triglycerides and wax esters, it serves as a genuine nutrient source for lipophilic microorganisms, notably yeasts of the genus Malassezia. These yeasts produce lipase enzymes capable of hydrolyzing sebum triglycerides and releasing free fatty acids. Among them, certain unsaturated fatty acids are known irritants: they disrupt the cohesion of corneocytes in the stratum corneum and increase the permeability of the skin barrier. Consequently, the skin becomes weakened, local inflammation sets in, and scaling intensifies.
Sebum also influences the bacterial population on the scalp. For example, Cutibacterium utilizes certain lipids as energy substrates. Its presence, beneficial under balanced conditions, is linked to the production of organic acids and antimicrobial compounds that limit the growth of competing bacteria such as Staphylococcus. An imbalance in sebum composition can therefore disadvantage some bacterial populations in favor of others, indirectly contributing to the development of dandruff.
Finally, beyond its composition, sebum also acts by modulating transepidermal water loss. Indeed, a deficiency or poor quality of sebum can exacerbate water leakage through the epidermis, further compromising the skin barrier. The study shows that areas of the scalp with elevated transepidermal water loss are also those where dandruff is most pronounced.
Sebum should not be viewed as an isolated factor but rather as a modulator of scalp homeostasis.