Symptômes xérose.

Xerosis: What are the symptoms?

Xerosis is a fairly common condition characterized by extremely dry skin. It can be occasional or chronic and is accompanied by several discomforts. What are the different symptoms of xerosis? Let's explore this question together.

Summary
Published February 13, 2025, updated on February 13, 2025, by Pauline, Chemical Engineer — 6 min read

What is xerosis?

Common with age, xerosis refers to a significant skin dryness resulting from a disruption in the skin barrier. Normally, water is retained in the skin due to the lipid organization in lamellar bilayers of the stratum corneum, the hydrolipidic film, and the natural moisturizing factor (NMF), such as urea and amino acids. When the synthesis of epidermal lipids, sebum, which partly composes the hydrolipidic film, or NMF decreases, the skin barrier weakens, making the skin more vulnerable to external aggressions, transepidermal water loss, and xerosis.

Several factors can disrupt the balance of the skin barrier and cause dry skin. Natural aging, for example, reduces sebum production and the synthesis of lipids in the stratum corneum, thus compromising the skin barrier function. Exposure to a cold and dry environment, especially in winter, also accelerates the evaporation of water, while the repeated use of hot water or harsh detergents dissolves the skin's protective lipids. Finally, dry skin can be exacerbated by an alteration of the skin microbiota, impacting the lipid structure of the epidermis.

The xerosis results from a complex interaction between biological, environmental, and microbial factors.

What are the manifestations of xerosis?

Xerosis is characterized by a variety of symptoms visible on the skin. If you are prone to this extreme skin dryness, you may observe one or more of the following signs, with varying degrees of severity:

  • Dry and rough skin.

    Cutaneous xerosis primarily manifests as skin losing its softness and becoming rough to the touch. This roughness is due to a change in the skin's surface, where the hydrolipidic film becomes almost nonexistent and a depletion of lipids makes the epidermis less flexible. After slight pressure, skin affected by xerosis may take longer to return to its original state, indicating a deterioration in its elasticity.

  • Feelings of tightness and discomfort.

    Another characteristic sign of xerosis: the sensations of skin tightness, which occur especially after showering or washing hands. They are particularly pronounced in areas prone to repeated stretching, such as the face, neck, and hands. The application of emollient and nourishing creams generally allows for the restoration of comfortable skin.

  • Itching.

    Xerosis cutis, or dry skin, can also cause itching, which can be either widespread or localized to certain parts of the body. This itching is sometimes accompanied by a tingling sensation or mild burning. It primarily affects areas with fewer sebaceous glands, such as the shins, where the alteration of the hydrolipidic film weakens the skin. With less protection, the skin becomes more susceptible to external aggressions, promoting the onset of irritation and tingling.

  • Redness and hypersensitivity.

    In some instances, xerosis (dry skin) is accompanied by a widespread redness that gives the skin an inflamed and sensitized appearance. This redness is often associated with hypersensitivity, making the skin reactive to the slightest touch or temperature change. Certain clothing textures, like wool, can become uncomfortable to the touch, and the application of warm to hot water can cause a burning or tingling sensation. This heightened reactivity is particularly common in areas most exposed to external aggressions, such as the face and hands.

    The inflammation sometimes observed in cases of xerosis can be explained by the stress experienced by keratinocytes due to dehydration. In response, these cells release danger-associated molecular patterns (DAMPs), which activate the local immune system. This leads to vasodilation, or an increase in the diameter of the capillaries, which in turn intensifies blood flow. These two factors visually manifest as the appearance of redness.

  • Flaking and cracking.

    When dryness intensifies, the skin begins to flake, meaning small scales gradually detach. This flaking is particularly noticeable in areas of friction, such as the knees and elbows. If no action is taken to combat the dryness, the skin can crack and microfissures can appear, especially on the heels and finger joints, where the skin undergoes significant mechanical stress.

Exemples cliniques de xérose cutanée.
Clinical examples of skin xerosis.
Source: STAUBACH P. & al. Diagnosis and treatment of xerosis cutis - a position paper. JDDG: Journal of the German Society of Dermatology (2019).

Sources

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