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Acetyl Tetrapeptide-2.

Commonly known as: Acetyl Tetrapeptide-2.

I.N.C.I. list name: Acetyl Tetrapeptide-2.

Extraction process: Chemical synthesis of peptides followed by N-acetylation.

Source: Synthetic.

Botanical name: /

Family: /

Part of the plant extracted: /

Provenance, origin: /

Chemical characteristics: Enzyme inhibiting peptide; Sequence of 4 amino acids (lysine-aspartic acid-valine-tyrosine); Peptide mimicking thymopoietin (hormone produced by the thymus); Molecular weight: 565.6 g/mol; Soluble in water; Insoluble in oil.

Characteristics: Colloidal solution, emulsion, true hydrophilic solution, gel.

Dosage required in cosmetic products: /

Function: Skin maintenance agent.

Properties: Firming, anti-inflammatory, nourishing, soothing, plumping, depigmenting.

Benefits: All skin types, particularly mature skin and skin prone to hyperpigmentation; All hair types.

Details

Properties

Anti-inflammatory: Stimulate the skin's immune defenses;
Depigmenting, lightening: Inhibiting the activity of tyrosinase, an enzyme responsible for the production of melanin, in order to reduce the appearance of brown spots;
Firming, plumping: Inducing the production of Type I collagen and functional elastin to compensate for their loss, and preventing their degradation by interfering with the enzymatic processes that break them down (metalloproteinases);
Regenerating: Increasing the proliferation of epidermal keratinocytes to strengthen the skin's barrier function against external factors and prevent water loss.

Applications

Facial Care (evening serums, eye serums/creams, face creams, cream-masks, lotions, gels, SPF creams);
Body Care (stretch mark body creams, lotions) ;
Hair Care (shampoos, conditioners).

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Method of Preservation

Keep it protected from light, moisture, and heat.

Contraindications, usage precautions.

The acetyl tetrapeptide-2 is considered to be non-hazardous and is well tolerated by all skin types.

Find out more

Acetyl tetrapeptide-2 is a biomimetic enzyme inhibiting peptide, derived from the youth hormone. It stimulates the structural elements of the skin, including collagen, fibrillin, and elastin, and maintains their properly assembled levels. It also prevents collagen degradation by interfering with the enzymatic processes that break it down. Additionally, it facilitates the union between cells and the extracellular matrix. Another study showed that acetyl tetrapeptide-2 contributes to hair regeneration and strengthening by increasing the proliferation of interfollicular keratinocytes and improving the synthesis of structural proteins in individuals prone to alopecia. Indeed, it aids hair growth due to its properties of inhibiting the catagen phase. In vitro, it has been shown that this peptide decreases the expression of TNF-alpha, a pro-apoptotic factor involved in shortening the anagen phase and inducing the catagen phase. Finally, acetyl tetrapeptide-2 also inhibits certain reactions in the melanogenesis process, thus reducing the appearance of pigmented spots.