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Acétyl tétrapeptide-3 dangers.

Are there any side effects from the topical application of Acetyl Tetrapeptide-3?

Acetyl Tetrapeptide-3 is an active ingredient commonly found in cosmetic hair care products. It has numerous benefits for hair application, as confirmed by several scientific studies. However, before using a product containing Acetyl Tetrapeptide-3, it's important to consider its potential side effects. Learn more about this by continuing to read.

Published February 22, 2024, by Pauline, Head of Scientific Communication — 3 min read

What is Acetyl Tetrapeptide-3?

Acetyl tetrapeptide-3 is a biomimetic peptide composed of a chain of four amino acids. This active ingredient is a synthetic compound used in the formulation of various cosmetic products. The acetyl tetrapeptide-3 is particularly used in hair care to prevent hair loss. This active ingredient is notably capable of stimulating the synthesis of certain proteins in the extracellular matrix such as type III collagen and laminin, which ensures a better anchoring to hair fibers.

increasing the size of hair follicles, which ensures better hair anchoring and thus reduces the risk of hair loss. It is also worth noting that studies have shown that the combination of acetyl tetrapeptide-3 and red clover extract is as effective, if not more so, than the drug minoxidil , which is widely used in cases of alopecia.

Adverse effects of acetyl tetrapeptide-3?

Acetyl Tetrapeptide-3 is a very gentle active ingredient whose topical use does not lead to any known side effects. In fact, there is no concentration limit for this ingredient in cosmetic products according to European regulations. These regulations are based on Regulation (EC) No 1223/2009, which establishes the standards and requirements that cosmetic products must meet in order to protect consumer health.

It should also be noted that the topical or hair application of a treatment based on acetyl tetrapeptide-3 is not discouraged for pregnant and/or breastfeeding women, nor for children over 3 years old. However, in accordance with the principle of precaution, it is advisable to perform a tolerance test before using a new product. The purpose of this test is to ensure that the application of a treatment does not cause redness, itching, or irritation on the skin. To perform the test, apply a small amount of the treatment to a small part of your face, in the crook of your elbow, or behind your ear. If you do not notice any adverse reaction within the following 24 hours, it means your skin tolerates the product well.


  • Règlement (CE) No 1223/2009 du Parlement Européen et du Conseil.

  • PANCHAPRATEEP R. & al. An herbal extract combination (biochanin A, acetyl tetrapeptide-3, and ginseng extracts) versus 3% minoxidil solution for the treatment of androgenetic alopecia: A 24-week, prospective, randomized, triple-blind, controlled trial. Journal of clinical and aesthetic dermatology (2020).


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