Cellulite: What are the effects of caffeine?

Also referred to as orange peel skin, the cellulite is the result of an accumulation of fats (adipose cellulite) or water (aqueous cellulite) in the hypodermis.

As a reminder, the skin is composed of 3 main layers: the epidermis, the dermis, and the hypodermis, each with its own role and unique characteristics. The epidermis is the outermost layer of the skin. Covered by a hydrolipidic film, it protects the skin from external aggressions (bacteria, wind, rain...) and maintains its hydration. The dermis, thick and elastic, also contributes to the protection of the skin, due to its thickness and the sebaceous glands it contains. These glands produce sebum, which partly constitutes the hydrolipidic film. Finally, the hypodermis is the deepest layer of the skin. Primarily composed of adipose cells, it serves as an energy reserve and plays a role in thermal insulation. The adipose cells are held together by collagen fibers.

Following the accumulation of fats or water, the cells of the hypodermis swell and cause the appearance of dimples on the skin's surface, giving it a bumpy appearance. The body areas where it often appears are the thighs, buttocks, stomach, and arms. However, it can be found in other locations depending on an individual's body shape. Cellulite primarily develops in women and is accompanied by a loss of skin tone and elasticity.

Cellulite can be caused by a hormonal surge during puberty, after pregnancy, or at the time of menopause. The increase in estrogen levels is accompanied by the stimulation of adipogenesis , the formation of adipocytes, which promotes the appearance of adipose cellulite. An unbalanced diet, sedentary lifestyle, stress, or smoking are other factors conducive to the development of cellulite.

Caffeine is primarily associated with an energizing effect in beverages. However, it is also a preferred ingredient in the design of skincare products. It is particularly used in the formulation of toning and draining products. Of plant origin, it is extracted from coffee, tea, guarana, mate, or kola nut.

Caffeine is an ingredient with interesting properties for combating cellulite. As a stimulant, it promotes lipolysis, the natural breakdown of lipids by the body. The small size of caffeine (MW = 194 g/mol) allows it to penetrate deeply into the skin. It has an inhibitory action on phosphodiesterases, enzymes specialized in the degradation of cyclic adenosine monophosphate (cAMP). This results in an increase in the level of cAMP in fat cells. This molecule notably controls the phosphorylation of certain lipases, that is, their activation. Lipases are enzymes that catalyze the reaction of lipolysis. Thus, caffeine triggers a cascade of reactions resulting in the reduction of fats in adipocytes.

Furthermore, caffeine has a decongesting power and draining effect and improves both blood and lymphatic circulation. This property is directly related to caffeine's ability to eliminate fats and toxins. The accumulation of these substances in the blood can lead to a loss of microcirculation efficiency and can promote the emergence of cellulite. Several studies have highlighted these properties and their benefits in alleviating certain circulation problems, such as dark circles or cellulite.