Polyglutamic acid in hair care.

The polyglutamic acid is an active ingredient derived from the polymerization of glutamic acid, which is obtained from the fermentation of soybean seeds. It is the main component of nattō, a Japanese dish made with fermented soybean seeds. However, the benefits of polyglutamic acid extend beyond the culinary field and into the cosmetic industry, where this active ingredient is primarily valued for its hydrating properties. This characteristic, appreciated by dehydrated skin, can also be beneficial for scalp care.

Polyglutamic acid could potentially hydrate the scalp.

Indeed, like the rest of the skin, the scalp can be subject to moisture imbalances, for instance due to frequent washing or sudden temperature changes. These imbalances can result in uncomfortable sensations of tightness or discomfort. The polyglutamic acid could help prevent and alleviate them. This active ingredient stands out for its ability to retain up to 5,000 times its weight in water, making it an excellent humectant. By forming a film on the skin's surface, it limits transepidermal water loss and promotes the maintenance of hydration in the upper layers of the scalp. Moreover, studies have shown that polyglutamic acid contributes to the integrity of the skin barrier by stimulating the production of certain molecules belonging to the natural moisturizing factor, such as lactic acid and urocanic acid. As a reminder, the natural moisturizing factor, also known as NMF, is a set of hygroscopic molecules that form during epidermal differentiation and whose role is to retain water in the stratum corneum.

Polyglutamic acid could soothe the scalp.

Beyond its hydrating abilities, polyglutamic acid also exhibits intriguing anti-inflammatory effects, particularly for irritated or sensitive scalps. Preclinical studies have shown that this active ingredient can significantly reduce the expression of vascular endothelial growth factor A (VEGF-A) and its receptor VEGFR2, key molecules in the processes of angiogenesis related to chronic inflammation. By decreasing these mediators, polyglutamic acid helps to limit the excessive proliferation of blood vessels and vascular permeability, which are responsible for the redness and swelling observed in inflammatory conditions.

Polyglutamic acid could potentially be a beneficial ingredient for sensitive scalps or those prone to itching or dehydration. However, this hypothesis still needs to be confirmed through clinical studies.