While these treatments are effective, they also present dermatological side effects. Calcipotriol can, in some cases, cause perilesional erythema and tingling or burning sensations at the applied sites. Calcitriol has these same side effects but at a lower frequency, and therefore the use of calcitriol is recommended in sensitive skin areas, such as flexion zones, retro-auricular, and facial areas.
Depending on the prescribed quantities, it is possible to observe irritative dermatitis in nearly 20% of cases. Contact allergic dermatitis, on the other hand, is less common. They are often accompanied by episodes of photosensitization, particularly in patients undergoing UVB phototherapy.
During treatment, a transient and mild hypercalcemia, with a twice-daily regimen of calcitriol, was observed in 5% of patients and resolved in four out of five individuals.
Pregnancy and breastfeeding are among the contraindications for treatment in the absence of sufficient data. Hypercalcemia is also contraindicated as calcitriol or calcipotriol tend to increase calcium absorption. This situation can be dangerous, as an excessive level of calcium can lead to various health problems. Generally, it is advised to take the time to carefully read the list of contraindications mentioned on the product currently in use.