The active molecules found in Ashitaba extract

TheAshitaba, botanically known as Angelica keiskei, is an endemic plant from Japan that belongs to the Apiaceae family, just like Angelica. The Japanese nickname it "tomorrow's leaf", because when a leaf is cut, it regrows the next day.

Known for nearly 2,000 years, it is renowned in traditional Asian medicine for promoting longevity. It is used in the preparation of stews or salads. It is also dried and consumed as tea.

For several years now, Ashitaba has been incorporated into skincare formulations in the field of cosmetology to combat skin aging. Indeed, the active molecules it contains endow it with interesting properties that allow it to be integrated into skin care treatments.

Anti-bacterial, anti-inflammatory...Ashitaba is a plant that owes its virtues to the active molecules it contains.

• Chalcones.

  Chalcones are one of the most abundant bioactive metabolites of Ashitaba, primarily found in the plant's root bark. These are yellow pigments derived from flavanones through the opening of the heterocycle. They are formed from phenylpropanoid and three molecules of malonyl-CoA. The resulting polyketide is folded by the chalcone synthase enzyme to promote Claisen condensations and subsequent enolizations.

  The 4-hydroxyderricin and the xanthoangelol, are the two most abundant chalcones in this plant. They possess cytotoxic and antidiabetic properties by increasing the activity of AMPK, an enzyme that plays a role in energy balance and reserves. They also have an anti-inflammatory activity by inhibiting a protein involved in an inflammatory process.

• Flavones.

  Flavones are a subfamily of flavonoids. These compounds are found in 42 plant families and are located in both above-ground and underground tissues. They are chalcones with a nucleophilic phenol group positioned near an α,β unsaturated ketone. Following a Michael reaction, a cyclization occurs, leading to the formation of flavones.

  Flavones are compounds of interest for combating free radicals by stabilizing them through a transfer of a hydrogen atom. Moreover, certain chalcones such as xanthoangelol or 4-hydroxyderricin are capable of inhibiting the activity of the PTP1B protein involved in the inflammatory process. These metabolites also possess antioxidant and chemopreventive effects.

• Coumarins.

  Coumarins are produced by the addition of a hydroxy group, either ortho or para, to a propanoid side chain of cinnamic acids. The coumarins derived from Ashitaba have cytotoxic, antidiabetic, anti-obesity, and antihypertensive properties.

  anti-inflammatory activities by inhibiting the activity of PTP1B.

• Other metabolites.

  The Ashitaba plant also contains other active molecules, such as active polyacetylenes, sesquiterpenes, triterpenes, and cyclohexenones.Ashitabaol is a particular sesquiterpene found in Ashitaba seeds that is believed to have a free radical scavenging activity.