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Effets pollution peau.

What are the effects of pollution on the skin?

As the first line of biological defense, the skin is constantly exposed to harmful compounds present in the environment. Beyond age and genetics, there are numerous factors capable of degrading skin quality. Indeed, exposure to atmospheric pollutants can quickly undermine the skin's normal protective role and induce a series of morphological changes through various mechanisms. In this article, we will review the consequences of urban pollution on the state of the skin.

Atmospheric Pollution: What are we talking about?

The term "air pollution" is a rather broad concept. It is defined by the World Health Organization (WHO) as "a contamination of indoor or outdoor air quality (homes, offices, etc.) by any suspended chemical, physical, or biological substance (aerocontaminants) that can alter the natural characteristics of the atmosphere". These pollutants, which encompass all gases and solid particles, come from various sources and can thus be:

  • of natural origin, for instance volcanic eruptions, desert dust, forest fires, biological decay, pollen, soil erosion, marshes, etc;

  • from anthropogenic sources, that is, resulting from human activity, such as thermal power plants, vehicle emissions, domestic combustion appliances (wood heating), agricultural activities, chemical and pharmaceutical industries, the burning of fossil fuels, the incineration of household garbage and industrial waste, etc.

We distinguish between "primary" pollutants, which originate from pollution sources. These include, for example, nitrogen oxides, sulfur dioxide, volatile organic compounds, hydrocarbons, and certain heavy metals. They can also be "secondary", meaning they are created by the atmosphere through complex physiochemical reactions between certain pollutants under the influence of specific weather conditions, involving notably ozone, nitrogen oxides, fine particles, etc. Although air pollution is most prevalent in urban environments and activity zones, rural areas are not necessarily spared.

PollutantsOrigins
Ammonia (NH3)Agricultural activities (volatilization during spreading and storage of livestock effluents, spreading of mineral fertilizers)
Volatile Organic Compounds (VOCs) (benzene, acetone, perchloroethylene...)Wood burning, automobile exhaust gases, use of household solvents (paints, glues, etc.)...
Sulfur Dioxide (SO2)Thermal power plants, residential heating, large industrial facilities, oil refining operations, combustion of fossil fuels (fuel oil, coal, diesel, etc.), volcanic eruptions...
Polycyclic Aromatic Hydrocarbons (PAHs)Incomplete combustion, use of solvents (paints, glues, coatings) and degreasers, cleaning products, filling of car tanks, cisterns, plastic production, pesticides, dyes, cigarette smoke, combustion of organic materials...
Heavy metals (lead, mercury, arsenic, cadmium, nickel)Incineration of household waste, metallurgical activities (mining, steel mills, manufacturing processes...), combustion of fossil fuels (coal, oil), road transportation, aviation, gunfire smoke...
Carbon Monoxide (CO)Industrial activities, fuel combustion, metallurgy...
Nitrogen Oxides (Nitric Oxide (NO) and Nitrogen Dioxide (NO2))Vehicle combustion engines, thermal power plants, residential heating, incineration plants, agriculture (use of nitrogen fertilizers), industrial processes (glassmaking, etc.), volcanoes, lightning, gas stoves...
Ozone (O3)Produced in the atmosphere due to the effects of solar radiation, heat, high electrical tension, or electrostatic discharges through complex reactions between certain primary pollutants (NOx, CO, VOCs)
Particles or suspended dust (PM2.5: particles with a diameter less than 2.5 micrometers; PM10: particles with a diameter less than 10 micrometers)Industrial or domestic combustion, diesel engines, residential heating, incinerators, sand mists, volcanic eruptions, forest fires...

The clinical manifestations of pollutants on the skin.

Indeed, chronic exposure to increasing amounts of all these forms of pollutants compromises the integrity of the skin. They exert their harmful effects by inducing oxidative stress in the skin tissues, with an overproduction of free radicals and reactive oxygen species, the peroxidation of polyunsaturated fatty acids, and a depletion of the enzymatic antioxidant capacity (glutathione peroxidase, superoxide dismutase, catalase, etc.) and non-enzymatic (vitamin C, vitamin E), which damage the barrier function of the epidermis. The main atmospheric pollutants that affect the skin are polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds, nitrogen oxides, airborne fine particles, ozone, and heavy metals.

Regardless of the entry route, either directly through the absorption of atmospheric pollutants through the skin (transdermal route) or via hair follicles, or indirectly through the absorption of particles by the lungs which are then transported by the blood to the skin, this disruption leads to the development of various skin issues, as soon as the normal defense potential of the skin is exceeded. Indeed, cells can no longer get rid of free radicals, thus slowing down the skin's repair mechanisms. Result : a whole series of inflammatory reactions is triggered and skin disorders can appear, sparing no skin type.

  • Accelerated aging.

    Several studies have shown that exposure to atmospheric pollutants contributes to accelerating the appearance of skin aging signs by penetrating the deep layers of the skin, including the formation of more pronounced wrinkles and elastosis. One of the main mechanisms through which ambient particles exert their harmful effects is the imbalance between the defense system and an excessive production of free radicals. They are thus responsible for a slowdown in cell renewal, lipid peroxidation, damage to the stratum corneum, and degradation of the fibers of collagen and elastin, which are vital elements of the extracellular matrix, following an upregulation of matrix metalloproteinases (MMP).

  • A dulling of the complexion.

    It has been demonstrated that carbon monoxide binds to hemoglobin, altering its conformation and reducing its ability to transport oxygen. This decrease in skin oxygenation can lead to a loss of radiance. Moreover, repeated exposure to these aggressions can trigger oxidative events that may disrupt the normal functioning of keratinocytes. The skin then regenerates more slowly and dehydrates more easily.

  • A loss of skin texture uniformity.

    Environmental pollution can also lead to acneiform eruptions, characterized by comedones and cysts, by acting at different levels. A study reported that ozone, along with long UVA rays and cigarette smoke rich in polycyclic aromatic hydrocarbons, are powerful oxidizing agents of squalene, an unsaturated lipid present in the sebum (10 - 15%) produced by the cells of the sebaceous glands (sebocytes) that is highly sensitive to oxidative processes related to the presence of six non-conjugated carbon double bonds. However, such a biochemical modification induces the formation of oxidized squalene by-products, mainly peroxidized forms, which then lead to an increase in comedones or even inflammatory acne.

    Furthermore, when oxidized, the elemental composition of oxidized squalene reveals an oxygen content of about 25%. This high value is likely to regulate the oxygen tension within the follicular canal, a critical factor in the survival and development of the resident anaerobic skin flora. Similarly, another study has shown that ambient air pollution can induce an abundance of Malassezia spp., commensal fungi on the skin, which could lead to a dysbiosis of the skin ecosystem and result in certain skin disorders.

  • A weakened and irritated skin.

    Several studies suggest that air pollution induces an inflammatory response in the epidermis, which can alter epidermal differentiation and, consequently, affect the skin's immune barrier. Indeed, the reactive oxygen species generated promote the maturation of pro-inflammatory mediators (IL-18 and IL-1β) in keratinocytes, leading to the accumulation of neutrophils and other phagocytic cells that in turn generate free radicals, thus creating a vicious cycle. They are also capable of increasing the expression of NF-kB, a transcription factor that regulates the expression of pro-inflammatory cytokines in epidermal cells. Pollutants also attack the lipids of skin cell membranes, making the skin more reactive and sensitive, which increases the risk of developing redness and sensitivities.

  • A loss of skin hydration.

    Pollution can lead to a dysfunction of the skin's protective barrier. For instance, fine airborne particles negatively impact the expression of hydrophobic epidermal lipids, including cholesterol sulfate, phospholipids, sphingomyelin, and glucosylceramides, which are key components of the barrier function. They also affect the expression of claudin-1, a significant protein that contributes to the integrity of tight junctions and are also capable of destroying keratin proteins that protect the skin from dehydration. On the other hand, exposure to ozone results in the formation of aldehydes and ozonation products of lipids, following the oxidation of unsaturated fatty acids in the upper layers of the epithelium (horny layer), damaging the barrier function of the epidermis. Studies have even shown that it can cause a depletion in tocopherol (vitamin E) and vitamin C, as well as an increase in malondialdehyde, a byproduct of lipid peroxidation, leading to an impairment of the barrier function.

  • A loss of skin tone uniformity.

    Several ethnically diverse cohort studies (Caucasians and Asians) have revealed that skin exposure to atmospheric pollutants (black carbon particles, polycyclic aromatic hydrocarbons, and heavy metals) is significantly correlated with the formation of more lentigines on the face and back of the hands. The activation of aryl hydrocarbon receptors (AhR) in melanocytes could provide a mechanistic explanation for these epidemiological observations.

    Indeed, fine particles laden with organic chemicals, such as AHs, which are highly lipophilic and easily penetrate the skin, would induce the proliferation of melanocytes associated with an increase in the transcription of genes involved in the synthesis de novo of melanin, and thus of skin pigmentation. This melanin synthesis would serve to protect the skin against oxidative stress induced by air pollution and therefore represents a skin defense strategy, knowing that eumelanin has antioxidant properties.

Sources

  • POLEFKA T. & al. Effects of environmentally realistic levels of ozone on stratum corneum function. International Journal of Cosmetic Science (2006).

  • KRUTMANN. Airborne particle exposure and extrinsic skin aging. Journal of Investigative Dermatology (2010).

  • SEITE S. & al. Pollution and skin: From epidemiological and mechanistic studies to clinical implications. Japanese Society for Investigative Dermatology (2014).

  • ROBERTS W. E. Pollution as a risk factor for the development of melasma and other skin disorders of facial hyperpigmentation ‐ Is there a case to be made? Journal of Drug in Dermatology (2015).

  • GARZA. Traffic-related air pollution contributes to development of facial lentigines: Further epidemiological evidence from Caucasians and Asians. Journal of Investigative Dermatology  (2016).

  • NGUYEN. Oxidization of squalene, a human skin lipid: a new and reliable marker of environmental pollution studies. International Journal of Cosmetic Science (2015).

  • WANG S. Q. & al. Recognizing the impact of ambient air pollution on skin health. Journal of the European Academy of Dermatology and Venereology (2015).

  • BERNARD B. A. & al. The skin aging exposome. Journal of Dermatological Science (2017).

  • MARROT L. & al. Photo-pollution stress in skin: Traces of pollutants (PAH and particulate matter) impair redox homeostasis in keratinocytes exposed to UVA1. Journal of Dermatological Science (2017).

  • RAMESH V. & al. Effects of air pollution on the skin: A review. Indian Journal of Dermatology, Venereology, and Leprology (2017).

  • ZHANG. Exposure to fine particulate matter associated with senile lentigo in Chinese women: a cross-sectional study. Journal of the European Academy of Dermatology and Venereology (2017).

  • KIM H. S. & al. Air pollution, autophagy, and skin aging: impact of particulate matter (PM(10)) on human dermal fibroblasts. International Journal of Molecular Sciences (2018).

  • SANTHANAM U. & al. Traffic‐derived air pollution compromises skin barrier function and stratum corneum redox status: A population study. Journal of Cosmetic Dermatology  (2019).

  • KELLY J. F. & al. Oxidative contribution of air pollution to extrinsic skin ageing. Free Radical Biology & Medicine (2020).

  • LUA B. L. & al. The effect of air pollution on the skin colour and tone of Chinese women: A multicentre cohort study. Skin Research and Technology (2020).

  • RANNUG A. & al. Involvement of arylhydrocarbon receptor (AhR-) signaling in skin melanogenesis. Journal of Investigative Dermatology (2020).

  • VALACCHI G. & al. Inflammasome activation in pollution-induced skin conditions. American Society of Plastic Surgeons (2020).

  • KRUTMANN J. & al. Air pollution-induced tanning of human skin. British Journal of Dermatology (2021).

  • ROBATI R. M. & al. The impact of air pollution on skin and related disorders: A comprehensive review. Dermatologic Therapy (2021).

  • CAVINATO M. & al. Effects of air pollution on cellular senescence and skin aging. Cells (2022).

  • LEE S.-S. & al. Detrimental correlation between air pollution with skin aging in Taiwan population. Medicine (2022).

  • THIO H. B. & al. Comparison of Malassezia spp. colonization between human skin exposed to high- and low-ambient air pollution. Experimental Dermatology (2022).

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