Rosacea: A Possible Link Between Gut and Skin Microbiota Raised?

The skin is one of the primary interfaces between our internal and external environments and is thus exposed to various assaults and variations to which it must adapt. It possesses a barrier function that is crucial, supported not only by its structure and composition, but also by the numerous microorganisms it harbors, constituting its natural microbiota.

The gut microbiota can affect the composition of this skin microbiota. Indeed, the bacteria present in the gut produce different types of short-chain fatty acids, or SCFAs, which then influence the microorganisms of the skin. One can notably take the example of Propionibacterium, an intestinal bacteria that synthesizes acetate and propionate. The latter has a antimicrobial effect against certain skin pathogens, like Staphylococcus aureus, even though it has no effect on Cutibacterium acnes, a bacteria involved in acne.

Rosacea is a chronic skin disease causing redness, small bumps, as well as tingling and itching. Although initially benign, it can have a significant impact on the quality of life of those who suffer from it, due to the physical and aesthetic discomfort it causes. Several factors have been identified as potentially triggering rosacea flare-ups , among which are diet, stress, and ambient temperature...

Some studies also suggest that there is a link between an imbalance of the gut or skin microbiota, also referred to as dysbiosis, and the development of rosacea. Indeed, it has been observed that the TLR-2 receptor of the epidermis, particularly activated by the mites Demodex, was upregulated in patients with rosacea. This activation by parasites triggers inflammatory mechanisms, including the synthesis of inflammatory prostaglandins IL-1β and IL-8. Furthermore, the chitin from the exoskeleton of the Demodex can also stimulate the pro-inflammatory response via the TLR-2.

Furthermore, a metagenomic study conducted on 12 patients with rosacea and 251 individuals not suffering from this condition showed that the gut bacteria Peptococcaceae and Methanobrevibacter were only present in individuals with rosacea while the bacteria Acidaminococcus and Megasphaera were significantly more abundant in patients with rosacea. Conversely, another study conducted on 11 patients and 110 controls observed a lower proportion of Acidaminococcus and Megasphaera in individuals affected by rosacea, contradicting the previous results.

Thus, the role of these various microorganisms in the pathophysiology of the disease remains to be precisely determined as the studies contradict each other. Moreover, at present, the scientific community does not know whether alterations in the skin and gut microbiota are potentiators of inflammation or secondary effects in response to changes in the skin or intestinal flora. That's why, although a link between the gut and skin microbiota and the development of rosacea has been observed, additional studies are still needed to precisely determine the mechanisms at work.