Saffron flower extract: an ingredient with multiple benefits for the skin.

The saffron has long been used for its therapeutic and healing virtues. These come from kaempferol, a molecule that stimulates the activity of the vascular endothelial growth factor (VEGF), whose role is to trigger the formation of new blood vessels (angiogenesis). In fact, a study conducted on mice showed that a loss of activity of this growth factor present in keratinocytes delayed wound healing.

Furthermore, saffron extract increases the production ofinterleukin-6 (IL-6). Although they are considered pro-inflammatory cytokines, it is commonly accepted that they possess skin regenerative activities, and they induce the migration and proliferation of keratinocytes. These various mechanisms through which saffron extract operates allow for a faster healing of minor wounds or light lesions.

Finally, saffron extract possesses moisturizing properties due to the polysaccharides it contains. These arehumectant agents whose molecular structure promotes the absorption and retention of water. The moisturizing power of saffron extract was indeed demonstrated in a recent study. This study involved 10 volunteers who daily applied a cream containing 3% saffron to their faces for 8 weeks.

An analysis using a cutometer subsequently showed that this treatment reduced transepidermal water loss (TEWL) by 7% and increased overall skin hydration by 8%. When incorporated into a cream or lotion, saffron extract thus contributes to skin hydration, which is essential for the skin to be supple and plump.

In vitro studies suggest that safranal, a molecule found in saffron extract, is capable of blocking the activity of elastase, collagenase, and hyaluronidase. These three enzymes respectively catalyze the degradation of elastin, collagen, and hyaluronic acid . These molecules are essential for skin flexibility, elasticity, and hydration. A decrease in any of these compounds promotes the appearance of wrinkles and skin sagging. By inhibiting these processes, saffron extract helps to delay skin aging.

Saffron extract also possesses photoprotective virtues, derived from the safranal it contains. Studies have shown that this compound has an SPF (Sunburn Protection Factor) of 6.6, which is quite low considering that a sun care product is considered effective when its SPF reaches 15. The SPF is the index measuring a product's ability to block UV rays responsible for sunburn. It has been shown that adding saffron extract to a chemical-based SPF 20 sun care product can increase the SPF by 43%.

The circadian cycle, repeated every 24 hours, regulates various biological processes in the body. Being directly exposed to light, skin cells play a role in this cycle. During prolonged exposure to UV rays, this rhythm can be disrupted, leading to disturbances on various scales. A study in vitro, conducted on human epidermal keratinocytes, focused on the expression of circadian cycle genes. Initially at 100%, this drops to 36% after 6 hours of exposure to UVB rays. The addition of 1% saffron extract in the culture medium allows the expression of these genes to maintain at 54% after 6 hours of exposure. Therefore, this ingredient helps to protect various biological processes from the deregulation caused by UV rays.

Due to its numerous benefits for the skin, Typology has incorporated saffron extract into its antioxidant serum. Enriched with antioxidant actives such as ferulic acid and Ashitaba extract (INCI: Angelica Keiskel Extract), this treatment protects the skin from oxidative stress caused by exposure to UV rays, pollution , or tobacco.

Furthermore, it slows down skin aging for a firmer and more radiant complexion. This serum should be applied morning and evening to a face that has been previously cleaned and dried. It is recommended to use it for at least four weeks to see the initial results.