In our quest for clearer skin, we often seek ingredients that deliver effective results without the harshness associated with some treatments. Succinic acid, a dicarboxylic acid, has emerged as a promising option for those dealing with acne. In this article, we explore the benefits and properties of succinic acid, shedding light on how it contributes to healthier skin.
- Carnet
- Active Ingredients
- Succinic acid to combat acne?
Succinic acid to combat acne?
- Understanding Acne Pathogenesis
- Antimicrobial Activity of Succinic Acid: Reducing Acne-Causing Bacteria
- Anti-Inflammatory Effects of Succinic Acid: Soothing Irritation
- Sebum Regulation by Succinic Acid: Balancing Oil Production
- Exfoliation and Acne: How Succinic Acid Helps Clear Pores
- Sources
Understanding Acne Pathogenesis.
Acne is a complex skin condition driven by multiple factors, including hyperseborrhea (excess oil production), hyperkeratinization (thickening of the skin), bacterial colonization (particularly Cutibacterium acnes), and inflammation. These processes lead to the formation of clogged pores and subsequent acne lesions. The overgrowth of C. acnes is a key factor in the progression of acne, as it contributes to both inflammation and the formation of pustules or cysts.
Recent studies highlight the beneficial role of succinic acid in addressing these core acne mechanisms. Succinic acid, a short-chain fatty acid, is produced during fermentation by commensal bacteria such as Staphylococcus epidermidis found on the skin. This acid has been shown to inhibit C. acnes growth, thereby reducing acne-related inflammation. Topical and intralesional applications of succinic acid have demonstrated effectiveness in suppressing C. acnes-induced inflammation both in vitro and in vivo. These findings suggest that succinic acid not only modulates the skin's microbiome but also holds promise as a therapeutic agent in acne treatment, offering a new approach by leveraging bacterial interactions on the skin.
Antimicrobial Activity of Succinic Acid: Reducing Acne-Causing Bacteria.
One of the key benefits of succinic acid is its antimicrobial activity. By inhibiting the growth of Cutibacterium acnes, the bacteria responsible for acne, succinic acid helps to prevent new blemishes from forming. This action is crucial in maintaining a clearer complexion, particularly for individuals prone to breakouts. The effectiveness of succinic acid in combating acne stems from its ability to disrupt bacterial cell membranes through a process called membrane permeabilization. This weakens the bacteria, leading to cell lysis and ultimately reducing the population of acne-causing bacteria on the skin. This property not only aids in preventing future breakouts but also contributes to an overall improvement in skin clarity.
Anti-Inflammatory Effects of Succinic Acid: Soothing Irritation.
Another notable benefit of succinic acid is its anti-inflammatory effect. Acne often brings about redness and irritation, which can exacerbate the condition. By incorporating succinic acid into our skincare regimen, we may experience reduced inflammation, leading to a calmer and more balanced complexion.
The anti-inflammatory properties of succinic acid work by modulating the immune response, specifically by inhibiting pro-inflammatory cytokines and chemokines. This modulation helps to alleviate the redness and swelling associated with acne lesions. Additionally, succinic acid can promote the production of anti-inflammatory mediators, further enhancing its ability to soothe irritated skin. This benefit is particularly advantageous for individuals who experience inflamed and irritated skin, as it promotes a more even skin tone and texture.
Sebum Regulation by Succinic Acid: Balancing Oil Production.
For those with oily skin typologies, regulating sebum production is essential in managing acne. Succinic acid aids in this aspect by balancing oil levels on the skin. By preventing excessive oiliness, we can reduce the likelihood of clogged pores and subsequent breakouts.
This property of succinic acid is especially beneficial for those with oily or combination skin typologies. It functions by modulating the activity of sebocytes, the cells responsible for sebum production. Additionally, by inhibiting the growth of acne-causing bacteria, succinic acid creates a less favorable environment for these microorganisms, further aiding in the regulation of sebum secretion. This dual action—controlling both oil production and bacterial presence—contributes to establishing an optimal environment for clearer skin. By effectively managing sebum levels, succinic acid addresses one of the fundamental causes of acne.
Exfoliation and Acne: How Succinic Acid Helps Clear Pores.
Succinic acid plays a vital role in exfoliating the skin, which is crucial for preventing acne. By gently removing dead skin cells and excess oils from the skin's surface, succinic acid helps to keep pores unclogged. Clogged pores are a primary contributor to acne breakouts, and exfoliation helps reduce this risk by ensuring that the pores stay clear of impurities. Succinic acid, when applied in a peel, aids in this delicate exfoliation process, leading to a smoother and clearer complexion. Regular use of succinic acid exfoliates the skin, removes buildup, and helps maintain a balanced skin texture, effectively supporting acne prevention.
The key takeaway.
By inhibiting the growth of Cutibacterium acnes, succinic acid helps prevent new acne blemishes and reduces the overall bacterial population on the skin.
Succinic acid soothes irritated skin by reducing redness and inflammation, providing a calmer complexion, especially for those dealing with inflamed acne lesions.
Succinic acid helps regulate sebum production, preventing excessive oiliness and reducing the risk of clogged pores, a primary cause of acne breakouts.
Succinic acid's exfoliating properties gently remove dead skin cells and excess oils, helping to keep pores clear and reducing the chances of new acne forming.
Sources
THIBOUTOT D. The role of follicular hyperkeratinization in acne. Journal of Dermatological Treatment (2000).
FARRAR M. & al. Acne: Inflammation. Clinics in Dermatology (2004).
CHIEN S. C. & al. Anti-inflammatory Activities of New Succinic and Maleic Derivatives from the Fruiting Body of Antrodia camphorata. Journal of Agricultural and Food Chemistry (2008).
ZOUBOULIS C. & al. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. Journal of the European Academy of Dermatology and Venereology (2014).
WANG Y. & al. Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris. Applied Microbiology and Biotechnology (2014).
PUROHIT A. & al. Anti-Salmonella Effects of Pyruvic and Succinic Acid in Combination with Oregano Essential Oil. Meat and Muscle Biology (2019).
FOURNIERE M. & al. Staphylococcus epidermidis and Cutibacterium acnes: Two Major Sentinels of Skin Microbiota and the Influence of Cosmetics. Microorganisms (2020).
STOICA C. & al. The role of skin microbiome in the pathogenesis of acne vulgaris. Revista Dermatovenerologica (2020).
CHUNG H. J. & al. Development and metabolic profiling of a postbiotic complex exhibiting antibacterial activity against skin microorganisms and anti-inflammatory effect on human keratinocytes. Food Science and Biotechnology (2022).
LIU H. & al. Role of succinic acid in the regulation of sepsis. International Immunopharmacology (2022).
GUERRA-TAPIA A. & al. A new topical biotechnological phytocomplex for truncal mild-moderate acne restores skin microbiota balance. Skin Research and Technology (2024).
DE LUCAS R. & al. New clinical approach in facial mild–moderate acne: Re-stabilization of skin microbiota balance with a topical biotechnological phytocomplex. Journal of Cosmetic Dermatology (2024).
Diagnostic
Understand your skin
and its complex needs.