The effects of turmeric on psoriasis?

The turmeric is among the most favored natural alternative solutions for targeting psoriasis. Whether it's added to the diet or used as a mask or cream, it has anti-inflammatory and healing properties. These various properties are primarily derived from the curcumin it contains.

This molecule also has the ability to limit the proliferation of keratinocytes, which is excessive in individuals suffering from psoriasis. This is due to its ability to prevent the synthesis of certain pro-inflammatory cytokines, such as interleukins 1α and 6 (IL-1α and IL-6). In addition to playing a role in the immune response, these cytokines act as a growth factor for keratinocytes. Their inhibition therefore helps to reduce keratinization. Furthermore, curcumin inhibits the production of prostaglandins, inflammatory molecules, which allows to reduce pain sensitivity.

One of the differences between the epidermis of a person suffering from psoriasis and that of a person not suffering from it is the level of expression of the enzyme phosphorylase kinase (PK). This protein normally regulates the processes of glycogenolysis and phosphorylation, but overactivity is associated with the symptoms of psoriasis. However, curcumin is a selective inhibitor of phosphorylase kinase and can reduce the expression of this protein and bring it back to normal levels. A study has notably shown that the daily application for 4 weeks of a cream with 1% curcumin could reduce the activity of PK by 85%. Given that the proportion of curcumin in turmeric powder is about 10%, it can be assumed that this ingredient has similar properties.

Finally, the healing power of curcumin has been demonstrated in several studies. This molecule notably accelerates epithelialization and angiogenesis, the synthesis of new blood vessels, by increasing the expression of the growth factor TGF-β1. Furthermore, curcumin prevents the depletion of glutathione, an antioxidant, and limits lipid peroxidation. This protects the cells of the epidermis and dermis, resulting in a better migration of fibroblasts at the wound site. It is also worth noting that curcumin inhibits the activity of matrix metalloproteinase-2 (MMP-2). This is a complex that triggers the synthesis of an enzyme whose role is to degrade collagen. By ensuring better stability for the latter, turmeric once again promotes epithelialization.

Note : If you are suffering from psoriasis, we advise you to consult with a general practitioner or a dermatologist who will guide you towards a comprehensive treatment, as turmeric can only be used as a supplement.