Thelightening virtuesof thetranexamic acid were recently discovered by a healthcare professional. While his patient was taking this molecule to treat his chronic urticaria, he observed a lightening and discoloration of his skin. This molecule has since proven to be just as effective for external use. How does tranexamic acid reduce the appearance of sunspots? How can it be used daily for this purpose? Answers to these questions are provided in this article.
Sun Spots: What effect does tranexamic acid have on this type of hyperpigmentation?
Summary
Published on September 13, 2022, updated on July 17, 2024, by Stéphanie, PhD, Doctorate in Life and Health Sciences — 5 min of reading
Themes:
What are sunspots?
Sun spots or lentigos are pigmented spots caused by a disruption in the pigmentation process (melanogenesis). The melanin, the pigment responsible for the natural coloration of the skin, is overproduced in certain areas, leading to the appearance of brown spots.
As we age, the functions of melanocytes, cells capable of producing melanin, become disrupted. The production of melanin becomes erratic, leading to the appearance of spots or solar lentigines in the most exposed areas (hands, face, décolletage, back, arms...). Even though these lesions are benign, some people may find them unattractive and wish to eliminate them. Tranexamic acid is a particularly effective active ingredient for reducing the appearance of these brown spots.
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How does tranexamic acid work against lentigines?
The exact mechanism of reduction of the melanogenesis by tranexamic acid remains unidentified to this day. However, several key elements have been highlighted by various studies.
Tranexamic acid inhibits the release of inflammatory mediators (arachidonic acid and prostaglandins) involved in triggering melanogenesis.
It blocks the interactions between melanocytes and keratinocytes (cells of the epidermis).
Tranexamic acid is structurally similar to tyrosinase, an enzyme that activates the oxidation of tyrosine, leading to the production of melanin. This competitive inhibition of the enzyme's active site blocks its activity and consequently the synthesis of melanin. The equation is simple: less tyrosine and less melanin means fewer pigments, fewer brown spots, and a more even complexion.
Thus, through these various actions, skincare products containing tranexamic acid are effective in reducing the appearance of sunspots. It should be noted, this compound should be introduced at a concentration ranging between 1 and 5%.
In which Typology skincare product can one find tranexamic acid?
Ourhyperpigmentation and firmness serumcontains 5% oftranexamicacid. This treatment reduces and prevents the appearance of pigmentation spots, particularly lentigos, and promotes skin firming.The complexion is even, the skin is smoother and firmer. It also containsacetyltetrapeptide-2, apeptidecomposed of four amino acids that stimulate the synthesis of key molecules involved in skin support and firmness: elastin, collagen, and fibrillin. This serum is applied morning and evening on clean, dry face.
To optimize the firming and anti-spot benefits of this treatment, you can follow this serum with aretinol face cream.Furthermore, it is strongly recommended to apply suitable sun protection to prevent the appearance of new brown spots and to minimize the progression of current marks over time. Every morning, apply a face sunscreen cream enriched with hydrating agents, such asaloe vera andhyaluronic acid. It provides broad-spectrum protection suitable for daily use.
Sources
E. Forbat, F. Ali and F. Al-Niaimi, The rising significance of tranexamic acid in dermatology, Clinical and Experimental Dermatology, (2019).
Aleksandra L. Lindgren,a Andrea H. Austin MD FAAD,b Kathleen M. The Use of Tranexamic Acid to Prevent and Treat Post-Inflammatory Hyperpigmentation, (2021)
