Bisabolol: What are its benefits for the scalp?

Bisabolol acts on scalp inflammations by soothing irritations and reducing itching sensations. Its anti-inflammatory properties operate at various levels within cells. Specifically, bisabolol can reduce the activity of several pro-inflammatory cytokines, such as interleukins-1β and 6 (IL-1β and IL-6) and tumor necrosis factor (TNF-α). Additionally, bisabolol downregulates cyclooxygenase 2 (COX-2), an enzyme that catalyzes the conversion of arachidonic acid into prostaglandin H2. Prostaglandins are compounds involved in inflammatory processes such as redness and itching.

A study conducted on 45 volunteers who underwent hair transplantation recently highlighted the soothing properties of bisabolol for the scalp. After their hair transplant, the individuals in the study had dry scalps, exhibited erythema, and experienced itching. After using a shampoo containing bisabolol for about twenty days, the researchers observed a significant reduction in the size of the crusts and erythema left by the transplant and a soothing of the itching. The concentration of bisabolol in the shampoo was not specified, but it can be assumed that it was between 0.1 and 2%, as other studies have shown that this active ingredient had a proven effectiveness from 0.1%, and that a concentration higher than 2% did not provide additional benefits.

Bisabolol has a protective effect on the scalp due to its antioxidant properties. Indeed, it is capable of trapping free radicals, the reactive species generated following prolonged exposure to UV rays, pollution, or tobacco, before they can damage our cells and our DNA. Additionally, bisabolol upregulates the activity of several antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), which are essential for the elimination of free radicals. Indeed, SOD catalyzes the dismutation of superoxide anions O2- into oxygen O2 and hydrogen peroxide H2O2. Catalase, on the other hand, ensures the dismutation of hydrogen peroxide into water and oxygen.

A hydrated scalp is less likely to be prone to tightness and irritation. Thanks to bisabolol, which acts as a humectant, the water present in the scalp's epidermis is retained and insensible water loss (IWL) is minimized. In this way, bisabolol helps to maintain the skin barrier.

Note : for a more comprehensive and complete hydration, bisabolol is typically combined with other active ingredients that have a stronger hydrating power, such as thehyaluronic acid or thealoe vera.

Bisabolol aids in accelerating the wound healing process. Thus, if you have a minor cut on your scalp, a bisabolol-based treatment can prove to be useful. Scientific studies have shown that this active ingredient is capable of acting on the fibroblast growth factor, and increasing its activity. This allows for the intensification of collagen and elastin secretion by the fibroblasts, which is essential for the formation of scar tissue. It has also been shown that bisabolol can promote the multiplication and migration of fibroblasts to the wound area.

For 1 in 2 people, dandruff is a common scalp disorder. Several factors have been identified as contributing to the onset of dandruff, among which is an overgrowth of Malassezia type fungi. By hydrolyzing the triglycerides present in sebum, these pathogens are responsible for the production of pro-inflammatory mediators. In addition to helping fight inflammation, bisabolol acts at the source and inhibits the synthesis of compounds essential to the integrity of the cellular membrane of the fungi. This dual action explains why it is frequently found in anti-dandruff shampoos.