Psoriasis versus Rosacea: What are the Similarities and Differences?

These two skin diseases exhibit certain similarities.

• Genetic predispositions.

  About 30% of psoriasis cases are said to be familial and appear during adolescence. There is not a single gene responsible for psoriasis disease but rather a set of genes. According to genetic linkage studies, PSORS1 has been identified as the main psoriasis susceptibility locus, contributing to about 35 to 50% of the disease's heritability. The PSORS1 region also encompasses the CDSN gene which codes for corneodesmosin, a desmosomal protein involved in the cohesion and desquamation of keratinocytes. This locus is associated with an early onset of the disease.

  It is estimated that nearly 30% of individuals suffering from rosacea have a family history of this condition, leading researchers to suggest the involvement of yet unidentified genes. One hypothesis considered is the prevalence in individuals with rosacea of certain receptors, such as the TRPA1 and TRVP1 receptors, which are involved in inflammatory processes.

• Non-communicable diseases.

  There are many misconceptions surrounding psoriasis and rosacea, particularly the belief that they are contagious. This misinformation often leads to social isolation for those affected. It is important to note that these two diseases are not contagious.

• A psychological impact.

  These two diseases exhibit visible symptoms, notably lesions, red patches, or pimples. These symptoms can have a significant psychological impact and can negatively affect the quality of life of patients.

• Incurable diseases.

  Psoriasis and rosacea are two diseases that progress in cycles. Symptoms can appear for weeks or months, then disappear before reappearing more pronounced. Although there are treatments to soothe the symptoms of the psoriasis and the rosacea, none of them can permanently cure these diseases.

While these two diseases share many similarities, they differ in certain aspects.

• Clinical manifestations.

  The psoriasis is characterized by the appearance of red patches covered with scales. Indeed, these are the result of a excessive proliferation of keratinocytes. Moreover, psoriasis patches are well defined. Conversely, rosacea presents redness due to the bursting of blood vessels.

• The affected areas.

  These two diseases do not affect exactly the same areas of the body. Rosacea is solely concentrated on the face, while psoriasis can affect the face but also the entire rest of the body.

• The associated symptoms.

  Beyond the presence of redness, psoriasis can cause itching, a burning sensation, and pain in the affected areas. On the other hand, in the case of rosacea, one often observes hot flashes, increased skin sensitivity, as well as burning and tingling sensations.