PRX-T33 is a biorevitalizing procedure designed to deeply regenerate the skin. What is the underlying principle of this technique, and how are the treatment sessions conducted? Here is everything you need to know.

Solution PRX-T33: what is this biorevitalization treatment with a peeling effect?
- What is PRX-T33?
- Is there clinical evidence supporting the efficacy of the PRX-T33 peel?
- How is a PRX-T33 biorevitalizing peel session performed?
- Sources
What is PRX-T33?
The PRX-T33 is a peeling biorevitalizing peel based on trichloroacetic acid (TCA) at 33%, which stimulates cellular regeneration in depth. It also contains hydrogen peroxide (67%), which moderates the action of TCA, allowing effective penetration without damaging the epidermis. The name PRX-T33 reflects both the composition and the function of the treatment: "P" for peeling (without visible exfoliation), "R" for revitalization, "X" to highlight the formula’s innovation, and "T33" to indicate the 33% trichloroacetic acid content.
The stimulation of cellular regeneration provided by PRX-T33 enables correction of imperfections and enhances skin radiance in a non-invasive manner. Thanks to its ability to rapidly penetrate the dermis, it reduces stretch marks, scars and pigmentation spots. This treatment helps combat loss of skin firmness on the face, décolletage, neck, or abdomen. Unlike traditional TCA peels, which are often abrasive and cause visible peeling, PRX-T33 works deeply without damaging the skin’s surface.
TCA, a powerful chemical exfoliant, penetrates the dermis where it stimulates fibroblasts to promote the production of collagen and elastin. However, thanks to the presence of hydrogen peroxide, its caustic effect on the epidermis is attenuated. This mechanism triggers skin regeneration processes without causing burns or visible peeling. TCA induces controlled coagulation of dermal proteins, initiating deep remodeling of the skin. Additionally, hydrogen peroxide not only moderates TCA’s aggressiveness but also enhances the penetration of active ingredients while stimulating growth factors. The kojic acid complements the treatment by targeting melanin production, helping to even out skin tone and diminish pigmented spots.
It should be noted that the PRX-T33 peel can be applied to the facial skin as well as other areas of the body. This biorevitalization technique is recommended as a complementary treatment alongside aesthetic procedures such as radiofrequency, laser therapy, or hyaluronic acid injections, among others. Unlike conventional peels, this gel can be used year-round, even on tanned skin during summer vacations. Finally, this peeling-effect biorevitalization treatment is suitable for all skin types and is not photosensitizing.
Is there clinical evidence supporting the efficacy of the PRX-T33 peel?
Since so few studies have focused on the PRX-T33 peel, one can cite a recent clinical trial comparing several approaches to improve the atrophic scars left by acne, which are often difficult to manage. The researchers conducted a randomized, double-blind clinical trial involving 120 patients divided into three groups: microneedling alone, PRX-T33 alone, or the combination of both techniques. Each participant underwent four sessions spaced 20 days apart, with clinical scar evaluations. The results show that the microneedling + peel combination produced a significantly greater improvement in scar appearance, as rated by evaluators, than either technique alone, suggesting the importance of pairing the PRX-T33 solution with another aesthetic medicine method, at least for acne scars.
Technique used | Clinical evaluation of post-treatment scars |
---|---|
Microneedling alone | 29% improvement |
PRX-T33 alone | 9% improvement |
Microneedling and PRX-T33 | 11.5% improvement |
How is a PRX-T33 biorevitalizing peel session performed?
During a PRX-T33 session, the first step is to thoroughly cleanse the skin and then dry it. The gel is applied to the target area with 2 to 5 applications per session. It is gently massaged until the formula is completely absorbed. The final step involves washing and rinsing the skin with a water-soaked pad. The full protocol typically includes 4 to 6 sessions performed on a weekly basis, each session lasting between 20 and 30 minutes.
Since the skin is temporarily weakened after this type of peel, applying a moisturizing and nourishing cream is recommended twice daily in order to restore the skin barrier, soothe any potential sensitivities and optimize the treatment’s effects.
Sources
WANG B. & al. Evidence and considerations in the application of chemical peels in skin disorders and aesthetic resurfacing. The Journal of Clinical Aesthetic Dermatology (2010).
BEDNARSKI I. A. & al. Double-blind, randomized controlled trial comparing the use of microneedling alone vs chemical peeling alone vs a combination of microneedling and chemical peeling in the treatment of atrophic post-acne scars: An assessment of clinical effectiveness and patients’ quality-of-life. Advances in Dermatology and Allergology (2021).
BIRON J.A. & al. Treatment of mild to moderate facial chrono- and photodamage with a novel intense liquid trichloroacetic acid peel. The Journal of Clinical and Aesthetic Dermaotology. (2022).
SMIT R. Evaluation of the efficacy of a TCA medium peeling procedure combined with skin biorevitalization in face rejuvenation: a case series. Journal of Dermatology and Cosmetology (2024).
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