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Gluconate de zinc acné

What are the benefits of zinc gluconate on acne?

Zinc gluconate is a stable form of zinc often incorporated into topical treatments for individuals with oily or acne-prone skin, as it is packed with benefits for these skin types. Let's delve deeper into the various virtues of zinc gluconate and how it can help combat acne.

Published February 23, 2024, by Pauline, Head of Scientific Communication — 7 min read

What are the causes of acne?

Acne is an inflammatory skin disease affecting nearly 80% of teenagers and young adults between the ages of 12 and 20. It often results from a imbalance in the production of sebum . Individuals suffering from acne typically have an increased sebum synthesis by the sebaceous glands. While sebum is essential for skin hydration and protection, overproduction can lead to blockage of the skin's pores and promote the appearance of imperfections, in the form of red pimples or whiteheads , or even nodules or cysts in the case of severe acne.

Furthermore, this increased sebum synthesis results in a greasy environment on the skin's surface, which is conducive to the proliferation of the bacterium Cutibacterium acnes. This microorganism, naturally present in hair follicles, feeds on the triglycerides found in sebum. In doing so, it produces free fatty acids that cause inflammation of the sebaceous glands.

Finally, the epidermis of acne-prone skin does not exfoliate as well as it should, leading to an accumulation of dead cells on the skin's surface, which can also clog the pores. Indeed, this follicular hyperkeratosis forms a keratinous plug that hinders the normal flow of sebum.

How does zinc gluconate work against acne?

Zinc, being unstable, cannot be directly incorporated into cosmetic products, which is why it is typically used in the form of zinc gluconate. This active ingredient, whose chemical formula is C12H22O14Zn, is composed of two gluconate anions, each carrying a negative charge, and a zinc cation, bearing two positive charges. The zinc gluconate is primarily known for its anti-inflammatory properties and its matifying effects, making it a valuable ally for acne-prone skin.

  • Zinc gluconate has sebum-regulating activity.

    The use of zinc gluconate helps regulate sebum production, a property beneficial for individuals suffering from acne. Indeed, a decrease in sebum synthesis is associated with a lower risk of pore obstruction, and therefore, a reduced likelihood of blemishes appearing.

    From a mechanistic perspective, zinc gluconate functions by inhibiting 5-α-reductase, the enzyme that catalyzes the conversion of testosterone into dihydrotestosterone (DHT). It's important to note that testosterone is produced in both men and women, although its synthesis is lower in the latter. DHT is an androgen hormone that binds to a specific cytosolic receptor located in the sebaceous glands. This binding triggers an increase in the activity of the sebaceous glands, and thus intensifies the synthesis of sebum. Zinc gluconate acts upstream of this reaction cascade and helps to keep sebum production under control.

  • Zinc gluconate possesses anti-inflammatory properties.

    Zinc gluconate can also function by reducing the inflammation of the sebaceous glands caused by acne. It has been particularly noted that this active ingredient is capable of inhibiting the production of the tumor necrosis factor TNF-α. This is a pro-inflammatory cytokine with both direct and indirect effects. TNF-α operates by releasing interleukins-1 and 6 (IL-1 and IL-6), other pro-inflammatory cytokines that heighten inflammation. By reducing the release of TNF-α, zinc gluconate helps to soothe the skin and protect it from inflammation.

  • Zinc gluconate has antibacterial properties.

    Zinc gluconate also works by fighting against Cutibacterium acnes, the bacteria partly responsible for acne. It inhibits the growth of these microorganisms and helps regulate the populations present on the surface of our skin. Several mechanisms of action are considered by the scientific community to explain the antibacterial effects of zinc gluconate. One of the most popular is that the zinc ions in zinc gluconate replace the magnesium ions involved in several enzymatic reactions essential to the proper functioning of the bacteria. In doing so, zinc gluconate prevents its growth.

How to use zinc gluconate against acne?

There are two primary ways to use zinc gluconate to combat acne: topical application and oral intake. Each method has its own advantages and disadvantages. Before choosing one method over the other, we recommend you seek advice from your doctor so they can provide guidance tailored to your specific situation.

  • The topical application of zinc gluconate.

    Zinc gluconate often comes in the form of gels or creams to be applied locally to areas where acne tends to appear. It turns out to be very effective when applied topically and has been the subject of several studies. One of these recently examined the effects of a cleansing gel containing 2% salicylic acid and 0.2% zinc gluconate. It involved 51 patients suffering from mild to moderate acne who were asked to apply the product to a wet face morning and evening for at least 30 seconds before rinsing with warm water. After 84 days, the researchers observed a global reduction of 60% in lesions, both inflammatory and non-inflammatory combined.

  • Oral intake of zinc gluconate.

    It is also possible to take zinc gluconate orally to combat acne, provided that the prescribed doses are strictly adhered to. It is generally recommended not to exceed 30 mg of zinc per day, which corresponds to 208 mg of zinc gluconate. A study on 30 patients notably showed that the daily administration of 30 mg of zinc gluconate for two months significantly reduced the number of inflammatory lesions. This treatment also helped to decrease the number of strains of Cutibacterium acnes resistant to erythromycin.

    Erythromycin is an antibiotic that was once commonly used against acne. Its use has gradually decreased as bacteria have become resistant to it over time. It would thus appear that the zinc gluconate and erythromycin are an interesting combination to mitigate and limit acne outbreaks.


  • RICHET H. & al. Effect of zinc gluconate on propionibacterium acnes resistance to erythromycin in patients with inflammatory acne: in vitro and in vivo study. European Journal of Dermatology (2005).

  • LE FLOCH C. & al. Assessment of the benefit of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acids 0.05% in patients with mild to moderate truncal acne: Results from an exploratory study. Clinical, Cosmetic and Investigational Dermatology (2023).


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