The hyaluronic acid is a glycosaminoglycan naturally present in the dermis and epidermis where it contributes to maintaining skin hydration. Its linear chemical structure, composed of repeating units of glucuronic acid and N-acetylglucosamine, gives it an exceptional capacity to capture and retain water. Indeed, a single molecule of hyaluronic acid can bind up to 1,000 times its weight in water, making it a reference humectant. This active ingredient is often likened to a molecular sponge. It is interesting to note that there are several forms of hyaluronic acid, which do not act in exactly the same way to preserve skin hydration.
Thus, high-molecular-weight hyaluronic acid (1,000–1,400 kDa) remains on the surface of the stratum corneum, forming a film that limits the evaporation of water molecules. Low-molecular-weight hyaluronic acid (20–300 kDa), by contrast, is able to penetrate the stratum corneum and lodge in the deeper layers of the epidermis and there retain water molecules diffusing toward the surface. Certain forms of low-molecular-weight hyaluronic acid can also stimulate the expression of genes involved in the synthesis of filaggrin and epidermal lipids, which are essential for the proper function of the skin barrier.
By combining different types of hyaluronic acid in a formulation, comprehensive skin hydration is achieved at various scales. That’s why hyaluronic acid is an essential for dry skin.
The hydrating properties of hyaluronic acid, whether applied topically or by injection, have been demonstrated in numerous studies. One such study was conducted by GIANNINI and his team in 2022. Over four months, the 46 participants applied twice daily a serum of hyaluronic acid (concentration unspecified). Hydration measurements were taken at each follow-up visit (weeks 2, 4, and 8), 15 minutes after cleansing, then 15 minutes after product application. The results showed a progressive and statistically significant improvement in hydration of the skin, both in the short and long term, with scores markedly higher than those recorded at the start of the study.